An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking
Summary: Response to multiple microenvironmental cues and resilience to mechanical stress are essential features of trafficking leukocytes.Here, we describe unexpected role of titin (TTN), the largest protein encoded by the human genome, in the regulation of mechanisms of lymphocyte trafficking.Human T and B lymphocytes express five TTN isoforms, e